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Alcohol consumption in rats also decreases the levels of THTR-1 and THTR-2 in renal epithelial cells, thus limiting thiamin re-uptake by the kidneys (133)

Food Research International, 50 (2), 562567

Linking the biological underpinnings of depression: role of mitochondria interactions with melatonin, inflammation, sirtuins, tryptophan catabolites, DNA repair and oxidative and nitrosative stress, with consequences for classification and cognition

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The researchers found that elevated IS levels in CKD patients correlate with oxidative stress and neuroinflammation, contributing to the deterioration of glial cells